Together, researchers have created a new classification system to help medical professionals identify those who would be at most risk for complications and may one day allow medical professionals to treat patients on a more personalized scale with much more effective treatments.
From the researchers’ analysis, they were able to identify five distinct clusters of diabetes that have distinct characteristics. SIRD, Severe InsulinResistant Diabetes, involved the highest levels of insulin resistance and offered the highest risk of diabetic kidney disease. MOD, Mild ObesityRelated Diabetes, is the most benign of the new classifications of diabetes. MARD, Mild Age-Related Diabetes, is another benign form of diabetes. SIDD, Severe Insulin-Deficient Diabetes solely effects young adults with poor metabolic control. Finally, Severe Autoimmune Diabetes overlaps with what we currently know as Type 1 Diabetes.
What these new classifications tell us is that it is possible to help identify those people at higher risk of complication and will give doctors a better guide for their treatment choice for their patients, especially for those suffering from the most severe forms of this disease – SIDD, Severe Insulin Deficient Diabetes, and SIRD, Severe Insulin-Resistant Diabetes. The risk of kidney complications is substantially increased with SIRD. With SIDD, the risk of diabetic retinopathy is higher. With this new-found knowledge, doctors could target individuals who fall into these categories and intensify their treatment regimes. In addition to those who meet the criteria for these classifications, a new classification system could benefit those who’ve suffered with diabetes 1 or 2 for many years. It would allow doctors to specifically target certain segments of their disease and could give them a clearer path forward.
This new classification system promotes the combination of different measurements to form a much more specific diagnosis and a targeted treatment plan by going beyond the simple glucose levels and looking at other factors. It is a precision oriented finding that could have lasting results for thousands of people around the world. In their opinion, this new system could represent a bold, new step in identifying and managing this deadly disease. The potential benefits for patients could be life-changing for patients worldwide.
THE CORRELATION BETWEEN DRINKING HEAVILY AND BRAIN HEALTH (ALCOHOL AWARENESS MONTH):
For years, research scientists and the medical community have known that there are negative long-term effects of heavy alcohol consumption, but until recently, they’d not yet studied with overconsumption of alcohol does to the brain long-term. Recent studies have pointed to significant brain damage as a result of heavy alcohol consumption. They’ve found that heavy drinking can’t kill brain cells as previously believed, but it does damage the dendrites. These are the branch-like ends of the brain cells. They are key components in passing messages from one neuron to another. Any degradation of the dendrites may cause significant cognitive impairment.
The research also suggests that any dendrite damage may be reverse with specific, targeted therapies and training, but there are no guarantees that those treatments will work in every case. Differing levels have damage can result in different outcomes.
Wernicke-Korsakoff Syndrome is another brain disorder that alcoholics could suffer from. In this condition, memory impairment, significant confusion, eye paralysis, and decreasing levels of muscle coordination significantly lessens the quality of life for those affected. In contrast to the previously discussed condition, this syndrome does not lead to brain cell death because it isn’t the result of the alcohol specifically. It occurs due to a thiamine deficiency.
Thiamine, an important B vitamin, is crucial to neuron health. Consuming large quantities of alcohol leads to a thiamine deficiency by disrupting the body’s ability to absorb it. Alcoholics tend to drink more of their calories, thus, making them malnourished. That malnourishment adds to the depletion of thiamine reserves in the body.
For years, we’ve been led to believe that brain cells are destroyed with high alcohol consumption. That’s a myth. There’s no evidence that moderate alcohol consumption kills brain cells or damages them in any way. In order to actually kill brain cells, one would have to consume a fatal amount of alcohol, thus, killing themselves in the process. While it’s now noted that there can be significant brain damage, none of the current evidence points to any actual brain cell damage. However, as noted previously, there is a strong correlation between consuming large quantities of alcohol and major impairments. There is also strong evidence that heavy consumption of alcohol leads to a vast array of social and socioeconomic problems.
As with any potential harmful substance, there are risks that need to be considered. Follow the healthcare guidelines to avoid these complications. If you believe you might have an alcohol problem, seek help before it’s too late. Much of the damage done as a result of heavy drinking cannot be reversed. Be proactive in your healthcare and seek help when needed. Rampant alcohol consumption may be seen as a harmless norm, but healthcare professionals and those struck with significant impairments know all too well just how life-altering the seemingly harmless substance can be. For more information about alcohol and how it can affect you, seek counsel from your healthcare provider and get the answers and resources you need to live a long, full life.